TYMP Human-Phosphorylase

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TYMP Human

Qty


Total
$65
Catalog #
ENPS-012
Size
Description
TYMP Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 493 amino acids (11-482 a.a.) and having a molecular mass of 51.3kDa. The TYMP is purified by proprietary chromatographic techniques.
Additional Information
IntroductionThymidine phosphorylase precursor (TYMP) is a platelet-derived endothelial cell growth factor that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate. TYMP is an angiogenic inducer that potently stimulates the growth of endothelial cells and induces chemotaxis. TYMP has a highly restricted target cell specificity acting only on endothelial cells. An increased expression of TYMP is found in a broad array of different solid tumors and inflammatory diseases and is frequently associated with poor prognosis. Mutations in the TYMP gene are linked to mitochondrial neurogastrointestinal encephalomyopathy.
SynonymsThymidine phosphorylase, Gliostatin, Platelet-derived endothelial cell growth factor, PD-ECGF, TdRPase, TYMP, ECGF1, TP, MNGIE, MEDPS1, MTDPS1, PDECGF, hPD-ECGF.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe TYMP solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
StabilityTYMP should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAPPAPGDFS
GEGSQGLPDP
SPEPKQLPEL
IRMKRDGGRL
SEADIRGFVA
AVVNGSAQGA
QIGAMLMAIR
LRGMDLEETS
VLTQALAQSG
QQLEWPEAWR
QQLVDKHSTG
GVGDKVSLVL
APALAACGCK
VPMISGRGLG
HTGGTLDKLE
SIPGFNVIQS
PEQMQVLLDQ
AGCCIVGQSE
QLVPADGILY
AARDVTATVD
SLPLITASIL
SK
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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