Dissolving Peptides|Support

For peptides that are not soluble in water, use the following procedure:

1. For acidic peptides, use a small amount of base such as 10% ammonium bicarbonate to dissolve the peptide, dilute with water to the desired concentration. Do not use base for cysteine-containing peptides.

2. For basic peptides, use a small amount of 30% acetic acid, dilute with water to the desired concentration.

3. For a very hydrophobic peptide, try dissolving the peptide in a very small amount of DMSO, dilute with water to the desired concentration.