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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Introduction | Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. It has been sµggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. Trx also provides control over a number of transcription factors affecting cell proliferation and death throµgh a mechanism referred to as redox regulation. |
| Synonyms | Thioredoxin-1, Thioredoxin I, TR-I, Thioredoxin-2, TRX1, TRX2, YLR043C. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Lyophilized Powder. |
| Formulation | Each mg of protein contains 20mM phosphate buffer pH 7.4. |
| Solubility | It is recommended to reconstitute the lyophilized TRX in sterile 18MΩ-cm H2O. |
| Stability | TRX althoµgh stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze thaw cycles. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Biological Activity | TRX activity is assayed by measuring the change in absorbance at 650 nm at 25°C using 0.13 |
| Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
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