Thrombin Human-Thrombin

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Thrombin Human

Qty


Total
$260
Catalog #
PRPS-1429
Size
Description
Recombinant Human Thrombin produced in HEK cells, having a total molecular weight of 36kDa. The Thrombin is purified by proprietary chromatographic techniques.
Additional Information
IntroductionThrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.
SynonymsProthrombin, EC 3.4.21.5, Coagulation factor II, F2, PT, THPH1, RPRGL2.
SourceHEK (HumaXpress).
Physical AppearanceSterile Filtered colorless solution.
FormulationThe Thrombin solution (1mg/ml) contains 20mM MES, pH6.0 and 500mM Choline Chloride.
StabilityStore frozen at -20°C to -80°C for long periods of time. Avoid multiple freeze-thaw cycles.
Biological Activity3000NIHU/mg protein.The activity was determined in NIH units by comparing to Sigma’s human plasma thrombin. Protein concentration was measured using E(0.1%)@280nm = 1.83.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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