SERPING1 Human-Serpin

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SERPING1 Human

Qty


Total
$65
Catalog #
PRPS-1408
Size
Description
SERPING1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 499 amino acids (23-500a.a) and having a molecular mass of 55.1kDa. SERPING1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionPlasma protease C1 inhibitor (SERPING1) is a part of the serpin superfamily of serine protease inhibitors. SERPING1 plays an important role in regulating activation of both the complement and contact systems. That isdue to the fact that SERPING1 regulates the activation of complement factor C1 in addition to the activity of activated C1 by coupling with the active catalytic site at the light chains of C1r and C1s. SERPING1 insufficiency results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa.
SynonymsC1IN, C1INH, C1NH, HAE1, HAE2 , Plasma protease C1 inhibitor, C1 esterase inhibitor, C1-inhibiting factor, Serpin G1, Name, SERPING1.
SourceE.coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationSERPING1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MNPNATSSSS
QDPESLQDRG
EGKVATTVIS
KMLFVEPILE
VSSLPTTNST
TNSATKITAN
TTDEPTTQPT
TEPTTQPTIQ
PTQPTTQLPT
DSPTQPTTGS
FCPGPVTLCS
DLESHSTEAV
LGDALVDFSL
KLYHAFSAMK
KVETNMAFSP
FSIASLLTQV
LLGAGENTKT
NLESILSYPK
DFTCVHQALK
GFTTKGVTSV
SQIFHSPDLA
IR
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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