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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Introduction | PI3Kg is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kg-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8a-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kg. |
| Synonyms | Phosphoinositide 3-kinase p110g, PI3Kg. |
| Source | Sf9 insect cells. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | Protein solution (1mg/ml) in 25mM Tris-HCl, pH 8.0, 50mM NaCl, 0.5mM MgCl2 and 50% glycerol. |
| Stability | PI3Kg althoµgh stable at 14°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Biological Activity | ~ 4.5 nmol/mg/min using phosphatidylinositol as the substrate. |
| Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
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