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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Introduction | Latent recombinant human pro-collagenase (MMP-13) also called collagenase-3 truncated from C-terminal.Matrix Metalloproteinase-13 (MMP-13) is an enzyme that is a member of the MMP extracellular protease family. Extracellular protease enzymes, by virtue of their broad substrate specificities1, play a role in both normal and disease states of tissue proliferation. Among the targets of MMP-13 are collagen, gelatin, entactin, pro-TNF-a, and chemokine SDF-11-4.MMP-13 is found in its latent form as a 52-56 kDa glycosylated proenzyme. Upon cleavage the 22-46 kDa5 MMP-1 becomes active in extracellular matrix remodeling.Because of the prominent role that MMP-1 plays in cell migration and metastasis, it is an important target for inhibition screening. |
| Synonyms | Collagenase 3, EC 3.4.24.-, Matrix metalloproteinase-13, MMP-13, CLG3. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | The MMP-13 protein solution (100 |
| Stability | MMP-13 althoµgh stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Biological Activity | Activity is determined by the cleavage of fluorogenic peptide, 50 ng of the MMP-13 enzyme will digest 75-80% (1.5-1.6 nmole) of fluorogenic peptide substrate (0.1ml of 20 |
| Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
| Applications | Used as a standard for assaying MMP-13 or for screening inhibitors. |
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