MAPK14 Human-Mitogen-Activated Protein

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MAPK14 Human

Qty


Total
$65
Catalog #
PKPS-021
Size
Description
MAPK14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 383 amino acids (1-360 a.a.) and having a molecular mass of 43.7kDa.MAPK14 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionMAPK14 belongs to the MAP kinase family and is most associated with p38 MAP kinases(MAPKs). MAPKs are activated mainly as a reaction to cellular stress and inflammatory cytokines, and inhibitors that target the MAPK14 and MAPK11 have demonstrated ability to cure inflammatory disease. The substrates of this kinase contain transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which demonstrate the parts of MAPK14 in stress-related transcription, cell cycle regulation and genotoxic stress response.
SynonymsMitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, CSBP1, CSBP2, Mxi2, PRKM14, MAP kinase p38 alpha, MAX-interacting protein 2, EXIP, PRKM15, p38, Cytokine suppressive anti-inflammatory drµg-binding protein, MAP kinase MXI2,
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationMAPK14 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 1mM DTT, 100mM NaCl and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSMSQERPT
FYRQELNKTI
WEVPERYQNL
SPVGSGAYGS
VCAAFDTKTG
LRVAVKKLSR
PFQSIIHAKR
TYRELRLLKH
MKHENVIGLL
DVFTPARSLE
EFNDVYLVTH
LMGADLNNIV
KCQKLTDDHV
QFLIYQILRG
LKYIHSADII
HRDLKPSNLA
VNEDCELKIL
DFGLARHTDD
EMTGYVATRW
YRAPEIMLNW
MHYNQTVDIW
SV
PurityGreater than 90.0% as determined by SDS-PAGE analysis.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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