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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Introduction | The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembranereceptorthat is activated by IGF-1and by the related growth factor IGF-II. It belongs to the large class of tyrosine kinasereceptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscleand other target tissues.IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and Beta-subunits, which are disulfide-linked in a Beta-alpha-alpha-Beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the Beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity. |
| Synonyms | Insulin-like growth factor 1 receptor, EC 2.7.10.1, Insulin-like growth factor I receptor, IGF-I receptor, CD221 antigen, CD221, IGFIR, JTK13, MGC18216, MGC142170, MGC142172. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered liquid. |
| Formulation | IGF-IR protein in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol. |
| Stability | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles. |
| Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
| Applications | ELISA, Inhibition Assays, Western Blotting. |
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