HPD Human-Oxygenase

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HPD Human

Qty


Total
$65
Catalog #
ENPS-022
Size
Description
HPD produced in E.Coli is a single, non-glycosylated polypeptide chain containing 413 amino acids (1-393a.a.) and having a molecular mass of 47kDa.HPD is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
Introduction4-Hydroxyphenylpyruvate Dioxygenase Isoform-1 is an Fe-containing enzyme, which catalyzes the second reaction in the catabolism of tyrosine the conversion of 4-hydroxyphenylpyruvate to homogentisate. Present as a homodimer, HPD uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Flaws in the gene encoding HPD result in tyrosinemia type 3 and hawkinsinuria, two inborn defects of metabolism which are related to a number of symptoms, like mental retardation and seizures and hair and urine abnormalities.
Synonyms4HPPD, GLOD3, 4-HPPD, PPD, HPPDase, Glyoxalase Domain Containing 3, 4-HydroxyphenylpYruvate Dioxygenase.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear solution.
FormulationThe HPD protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 1mM DTT, 50mM NaCl and 20% glycerol.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MTTYSDKGAK
PERGRFLHFH
SVTFWVGNAK
QAASFYCSKM
GFEPLAYRGL
ETGSREVVSH
VIKQGKIVFV
LSSALNPWNK
EMGDHLVKHG
DGVKDIAFEV
EDCDYIVQKA
RERGAKIMRE
PWVEQDKFGK
VKFAVLQTYG
DTTHTLVEKM
NYIGQFLPGY
EAPAFMDPLL
PKLPKCSLEM
IDHIVGNQPD
QEMVSASEWY
LKNLQFHRFW
SV
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoBiolabs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
StorageStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Background

N/A

Protocol

N/A

MSDS
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