HMBS Human-Synthase

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HMBS Human

Qty


Total
$65
Catalog #
ENPS-588
Size
Description
HMBS Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 385 amino acids (1-361) and having a molecular mass of 41.9kDa.HMBS is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionPorphobilinogen deaminase (HMBS) belongs to the hydroxymethylbilane synthase superfamily. HMBS is a cytoplasmic enzyme found in the heme synthesis pathway. HMBS is the 3rd enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of 4 porphobilinogen molecules into the linear hydroxymethylbilane. HMBS gene mutations cause errors in pyrrole metabolism which in turn lead to the autosomal dominant disease acute intermittent porphyria.
SynonymsPorphobilinogen deaminase, PBG-D, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase, HMBS, PBGD, UPS, PORC.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe HMBS solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMSGNGN
AAATAEENSP
KMRVIRVGTR
KSQLARIQTD
SVVATLKASY
PGLQFEIIAM
STTGDKILDT
ALSKIGEKSL
FTKELEHALE
KNEVDLVVHS
LKDLPTVLPP
GFTIGAICKR
ENPHDAVVFH
PKFVGKTLET
LPEKSVVGTS
SLRRAAQLQR
KFPHLEFRSI
RGNLNTRLRK
LDEQQEFSAI
ILATAGLQRM
GWHNRVGQIL
HP
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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