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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Introduction | Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA. |
| Synonyms | NULL |
| Source | NULL |
| Formulation | (1mg/ml) 50mM Tris-HCl pH 8.5, 5mM DTT, 10mM BMe and 8M Urea. |
| Purity | HBV HBe protein is >95% pure as determined by 10% PAGE (coomassie staining). |
| Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
| Applications | HBV HBe antigen is suitable for ELISA and Western blots, excellent antigen for detection of HBV with minimal specificity problems. |
| Storage | HBV HBe protein althoµgh stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. |
| Purification Method | Purified by proprietary chromatographic technique. |
| Specificity | Immunoreactive with sera HBV-infected individuals. |
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