Accelerate Biological Research
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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Introduction | Prouroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen.Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leading to elevated blood pressure independent of the level of diatary salt intake.Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids. |
| Synonyms | Guanylate cyclase activator 2B, UGN, GCAP-II, GUCA2B. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | Sterile filtered and lyophilized from 0.5 mg/ml in 50mM Phosphate buffer pH-7.4. |
| Solubility | Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely. |
| Stability | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated thaw-freeze cycles and store at -80°C. Reconstituted protein can be stored at 4°C for a limited period of time. |
| Purity | Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
| Purification Method | Three-step procedure using IMAC and size exclusion chromatography before and after refolding. |
| Specificity | The recombinant sequence is 100% homologous to the native human sequence. |
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