GMDS Human-Hydratase

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GMDS Human

Qty


Total
$65
Catalog #
ENPS-198
Size
Description
GMDS Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 392 amino acids (1-372) and having a molecular mass of 44.1 kDa.GMDS is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionGMDS is a member of the GDP-mannose 4,6-dehydratase family. GMDS uses NADP as a cofactor to catalyze the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose. Defects in the gene encoding GMDS cause TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis.
SynonymsGDP-mannose 4,6-dehydratase, GMD, SDR3E1, short chain dehydrogenase/reductase family 3E member 1, GDP-D-mannose dehydratase, EC 4.2.1.47.
SourceE.coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe GMDS solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl, 0.1mM PMSF and 30% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAHAPARCPS
ARGSGDGEMG
KPRNVALITG
ITGQDGSYLA
EFLLEKGYEV
HGIVRRSSSF
NTGRIEHLYK
NPQAHIEGNM
KLHYGDLTDS
TCLVKIINEV
KPTEIYNLGA
QSHVKISFDL
AEYTADVDGV
GTLRLLDAVK
TCGLINSVKF
YQASTSELYG
KVQEIPQKET
TPFYPRSPYG
AAKLYAYWIV
VNFREAYNLF
AVNGILFNHE
SP
PurityGreater than 95% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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