GLO1 Human-Other

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GLO1 Human

Qty


Total
$65
Catalog #
ENPS-405
Size
Description
Glyoxalase-I Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 184 amino acids and having a molecular mass of 20.7 kDa. Glyoxalase-1 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionGLO1 is involved in the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. GLO1 is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. GLO1 enzyme is ubundantly expressed and present in numerous tumor cell lines, in which its concentration is often upregulated ubiquitisly. GLO1 is a major susceptible gene for autism in an ethnic Chinese population from Taiwan. GLO1 might be involved in the pathophysiology of mood disorders. GLO1 plays a role in the pathophysiology of mood disorders. Overexpression of GLO1 is associated with kidney tumor.
SynonymsGLYI, GLOD1, GLO1, Glyoxalase-1, Lactoylglutathione lyase, Methylglyoxalase, Aldoketomutase, Ketone-aldehyde mutase, Glyoxalase I, S-D-lactoylglutathione methylglyoxal lyase, Glx I.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationGlyoxalase-1 solution containing 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMAEPQPPSGG
LTDEAALSCC
SDADPSTKDF
LLQQTMLRVK
DPKKSLDFYT
RVLGMTLIQK
CDFPIMKFSL
YFLAYEDKND
IPKEKDEKIAWALSRKATLE
LTHNWGTEDD
ETQSYHNGNS
DPRGFGHIGI
AVPDVYSACK
RFEELGVKFV
KKPDDGKMKG
LAFIQDPDGY
WIEILNPNKM
ATLM.
PurityGreater than 90.0% as determined by SDS-PAGE.
Biological Activity>0.4 units/mg. One unit will form 1.0 umol of S-lactoylglutathione from methylglyoxal and reduced glutathione per minute at pH 7.5, at 25C.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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