DUT Human-Phosphatase

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DUT Human

Qty


Total
$65
Catalog #
ENPS-575
Size
Description
DUT Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 204 amino acids (70-252 a.a.) and having a molecular mass of 21.6kDa. The DUT is purified by proprietary chromatographic techniques.
Additional Information
IntroductionDeoxyuridine Triphosphatase (DUT) is a ubiquitous enzyme that functions in nucleotide metabolism. Deoxyuridine Triphosphatase, in the presence of magnesium ions, is responsible for hydrolyzing dUTP to dUMP and diphosphate. This reaction is imperative for keeping the intracellular dUTP concentration low so that uracil does not become incorporated into DNA. Extensive integration of uracil into DNA can eventually lead to cell death. This sµggests that DUT is crucial for cell viability, further implying that it is a NeoBiolabtive target for anticancer therapy.
SynonymsDeoxyuridine 5''-triphosphate nucleotidohydrolase mitochondrial, dUTPase, dUTP pyrophosphatase, Deoxyuridine Triphosphatase, DUT, FLJ20622.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe DUT solution (1 mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 10% glycerol, 1mM DTT and 0.1M NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MASTVGAAGW
KGELPKAGGS
PAPGPETPAI
SPSKRARPAE
VGGMQLRFAR
LSEHATAPTR
GSARAAGYDL
YSAYDYTIPP
MEKAVVKTDI
QIALPSGCYG
RVAPRSGLAA
KHFIDVGAGV
IDEDYRGNVG
VVLFNFGKEK
FEVKKGDRIA
QLICERIFYP
EIEEVQALDD
TERGSGGFGS
TGKN.
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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