CTDSP1 Human-Phosphatase

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CTDSP1 Human

Qty


Total
$65
Catalog #
ENPS-117
Size
Description
CTDSP1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 280 amino acids (1-260 a.a.) and having a molecular mass of 31.2kDa.CTDSP1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionCTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. CTDSP1 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. In addition, CTDSP1 negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
SynonymsCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, NLI-IF, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, SCP1, Small CTD phosphatase 1, CTDSP1, NIF3, NLIIF.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationCTDSP1 solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 20% glycerol and 0.1M NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MDSSAVITQI
SKEEARGPLR
GKGDQKSAAS
QKPRSRGILH
SLFCCVCRDD
GEALPAHSGA
PLLVEENGAI
PKTPVQYLLP
EAKAQDSDKI
CVVIDLDETL
VHSSFKPVNN
ADFIIPVEID
GVVHQVYVLK
RPHVDEFLQR
MGELFECVLF
TASLAKYADP
VADLLDKWGA
FRARLFRESC
VFHRGNYVKD
LSRLGRDLRR
VLILDNSPAS
YV
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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