Accelerate Biological Research
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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Introduction | CDK2AP1 is a CDK2-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. CDK2AP1 interacts with DNA polymerase alpha and mediates the phosphorylation of the large p180 subunit, which implicates the regulatory role in DNA replication during S phase of the cell cycle. |
| Synonyms | Cyclin-dependent kinase 2-associated protein 1, CDK2-associated protein 1, Putative oral cancer suppressor, Deleted in oral cancer 1, DOC-1, CDK2AP1, CDKAP1, DOC1, ST19, DORC1, p12DOC-1. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered clear colorless solution. |
| Formulation | The CDK2AP1 solution contains 20mM Tris-HCl pH-8, 0.1M NaCl and 20% glycerol. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Amino Acid Sequence | RGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSY KPNLAAHMPA AALNAAGSVH SPSTSMATSS QYRQLLSDYG PPSLGYTQGT GNSQVPQSKY AELLAIIEEL GKEIRPTYAG SKSAMERLKR GIIHARGLVR ECLAETERNA RS. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
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