CDK2 Human-Cyclin-Dependent Kinase

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CDK2 Human

Qty


Total
$65
Catalog #
PKPS-015
Size
Description
CDK2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 306 amino acids (1-298 a.a.) and having a molecular mass of 35kDa.CDK2 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionCyclin-dependent kinase 2 (CDK2) belongs the Ser/Thr protein kinase family. CDK2 is highly parallel to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is limited to the G1-S phase, and is vital for cell cycle G1/S phase transition. The CDK2 protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). CDK2 activity is also regulated by protein phosphorylation.
SynonymsCyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDK2, CDKN2, p33(CDK2).
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationCDK2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMENFQKVEKI
GEGTYGVVYK
ARNKLTGEVV
ALKKIRLDTE
TEGVPSTAIR
EISLLKELNH
PNIVKLLDVI
HTENKLYLVF
EFLHQDLKKF
MDASALTGIP
LPLIKSYLFQ
LLQGLAFCHS
HRVLHRDLKP
QNLLINTEGA
IKLADFGLAR
AFGVPVRTYT
HEVVTLWYRA
PEILLGCKYY
STAVDIWSLG
CIFAEMVTRR
ALFPGDSEID
QLFRIFRTLG
TPDEVVWPGV
TS
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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