CDA Human-Deaminase

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CDA Human

Qty


Total
$65
Catalog #
ENPS-014
Size
Description
CDA Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 166 amino acids (1-146 a.a.) and having a molecular mass of 18.3kDa. The CDA is purified by proprietary chromatographic techniques.
Additional Information
IntroductionCytidine deaminase (CDA) is an enzyme that scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. CDA is one of several deaminases responsible for maintaining the cellular pyrimidine pool. CDA also catalyzes the deamination of chemotherapeutic cytosine nucleoside analogs such as Ara-C and 5-azacytidine, which results in the loss of their cytotoxic and antitumor function. CDA can form homotetramers and is generally expressed in granulocytes. Mutations in the CDA gene are linked to decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
SynonymsCytidine deaminase, Cytidine aminohydrolase, CDA, CDD.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe CDA solution (0.5 mg/ml) contains 20 mM Tris-HCl Buffer (pH 8.0), 1 mM DTT, 2mM EDTA, 100 mM NaCl and 40% Glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAQKRPACTL
KPECVQQLLV
CSQEAKQSAY
CPYSHFPVGA
ALLTQEGRIF
KGCNIENACY
PLGICAERTA
IQKAVSEGYK
DFRAIAIASD
MQDDFISPCG
ACRQVMREFG
TNWPVYMTKP
DGTYIVMTVQ
ELLPSSFGPE
DLQKTQ.
PurityGreater than 90.0% as determined by SDS-PAGE.
Biological ActivitySpecific activity :> 3.5unit/mg. One unit of activity was defined as the amount required to deaminate 1.0 umole of cytidine per min at pH 7.5 at 250C.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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