BLK Human-Protein Kinases

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BLK Human

Qty


Total
$65
Catalog #
PKPS-278
Size
Description
BLK Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 525 amino acids (1-505 a.a.) and having a molecular mass of 59.8kDa.BLK is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionB lymphoid kinase (BLK) is a 55kDa tyrosine kinase with SH3, SH2, and catalytic domains which contain consensus sequences of the Src protein tyrosine kinase family. BLK is a nonreceptor tyrosine-kinase belonging to the src family of proto-oncogenes which are typically involved in cell proliferation and differentiation. The BLK protein is expressed specifically in the B cell lineage and has a role in the signal-transduction pathway which is restricted to B lymphoid cells. In addition, BLK stimulates insulin synthesis and secretion in response to glucose and increases the expression of several pancreatic beta-cell transcription factors.
SynonymsTyrosine-protein kinase Blk, B lymphocyte kinase, p55-Blk, BLK, MODY11, MGC10442.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationBLK protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.1M NaCl, 1mM DTT and 0.1mM PMSF.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGLVSSKKPD
KEKPIKEKDK
GQWSPLKVSA
QDKDAPPLPP
LVVFNHLTPP
PPDEHLDEDK
HFVVALYDYT
AMNDRDLQML
KGEKLQVLKG
TGDWWLARSL
VTGREGYVPS
NFVARVESLE
MERWFFRSQG
RKEAERQLLA
PINKAGSFLI
RESETNKGAFSLSVKDVTTQ
GELIKHYKIR
CLDEGGYYIS
PRITFPSLQA
LVQHYSKKGD
GLC
PurityGreater than 80.0% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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