BAG2 Human-B Cell Lymphoma

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BAG2 Human

Qty


Total
$65
Catalog #
PRPS-175
Size
Description
BAG2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 231 amino acids (1-211 a.a.) and having a molecular mass of 25.9kDa. The BAG2 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionBCL2-associated athanogene 2 (BAG2) belongs to the Bag family of proteins. BAG2 is a chief component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to upset CHIP-mediated ubiquitylation. BAG proteins compete with Hip for attaching to the Hsc70/Hsp70 ATPase domain and promote substrate discharge. All the BAG proteins have a roµghly 45 amino acid BAG domain by the C-terminus but vary clearly in their N-terminal regions. The BAG domains of BAG1, BAG2, and BAG3 act together expressly with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins attach with high affinity to the ATPase domain of Hsc70 and obstruct its chaperone activity in a Hip-repressible manner.
SynonymsBAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2, KIAA0576, MGC149462, dJ417I1.2.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe BAG2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 20% glycerol and 0.1M NaCl.
StabilityBAG2 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAQAKINAKA
NEGRFCRSSS
MADRSSRLLE
SLDQLELRVE
ALREAATAVE
QEKEILLEMI
HSIQNSQDMR
QISDGEREEL
NLTANRLMGR
TLTVEVSVET
IRNPQQQESL
KHATRIIDEV
VNKFLDDLGN
AKSHLMSLYS
ACSSEVPHGP
VDQKFQSIVI
GCALEDQKKI
KRRLETLLRN
IENSDKAIKL
LEHSKGAGSK
TLQQNAESRF
N.
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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