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Our customer service representatives are available 24 hours, Monday through Friday to assist you.Reactivity | Human Mouse Rat |
Tested applications | WB IHC ICC IF FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IF 1:50 - 1:200 FC 1:20 - 1:50 |
Calculated MW | 55 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human UBB |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | HEL-S-50; |
Immunohistochemistry of paraffin-embedded mouse brain using UBB antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse testis using UBB antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse placenta using UBB antibody at dilution of 1:100 (40x lens).
Immunofluorescence
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.
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