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Tested applications | WB |
Recommended Dilution | WB 1:200 - 1:2000 |
Calculated MW | 68kDa |
Observed MW | Refer to figures |
Immunogen | A synthetic Peptide of human RAPGEF5 |
Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | GFR; REPAC; MR-GEF; |
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000
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