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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Reactivity | Human |
| Tested applications | IHC |
| Recommended Dilution | IHC 1:50 - 1:100 |
| Calculated MW | 110kDa |
| Observed MW | Refer to Figures |
| Immunogen | A phospho specific peptide corresponding to residues surrounding T645 of human STAT6 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | ko |
| Synonym | STAT6B; STAT6C; D12S1644; IL-4-STAT; |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
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