Phospho-STAT5A-Y694-Polyclonal Antibodies

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Phospho-STAT5A-Y694

Qty


Total
$300
Catalog #
AP0138
Antibody Type
Polyclonal Antibody
Gene ID
6776
Swiss Prot
P42229
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:100
Calculated MW90kDa
Observed MWRefer to Figures
ImmunogenA phospho specific peptide corresponding to residues surrounding Y694 of human STAT5A
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbko
SynonymMGF; STAT5;
Images
  • AP0138: image 1

    Western blot analysis of extracts from K562 cells using Phospho-STAT5A-Y694 antibody.

  • AP0138: image 2

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Phospho-STAT5A-Y694 antibody.

Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Protocol

N/A

MSDS
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