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Tested applications | WB |
Recommended Dilution | WB 1:500 - 1:2000 |
Observed MW | Refer to Figures |
Immunogen | A phospho specific peptide corresponding to residues surrounding S450 of human MDM2 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | fl |
Synonym | HDMX; hdm2; ACTFS; MGC5370; MGC71221 |
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3).
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