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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Reactivity | Human Mouse |
| Tested applications | WB |
| Recommended Dilution | WB 1:500 - 1:2000 |
| Calculated MW | 15kDa |
| Observed MW | Refer to Figures |
| Immunogen | A phospho specific peptide corresponding to residues surrounding S139 of human H2AFX |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | H2A.X; H2AFX; H2a/x; HIST5-2AX; |
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
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