Accelerate Biological Research
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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Calculated MW | 12kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human INS |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | p |
| Synonym | ILPR; IRDN; IDDM2; MODY10; Insulin; |
Western blot analysis of extracts of mouse pancreas cells, using INS antibody.
Immunohistochemistry of paraffin-embedded rat brain using INS antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate using INS antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using INS antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using INS antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using INS antibody at dilution of 1:100 (40x lens).
The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic β cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).
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