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Our customer service representatives are available 24 hours, Monday through Friday to assist you.Reactivity | Human Mouse Rat |
Tested applications | WB IHC IF |
Recommended Dilution | WB 1:200 - 1:500 IHC 1:100 - 1:200 IF 1:20 - 1:50 |
Calculated MW | 18kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human IL17A |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | b |
Synonym | IL17A;CTLA8;IL-17;IL-17A;IL17 ; |
Western blot analysis of extract of various cells, using IL17A antibody.
Immunohistochemistry of paraffin-embedded mouse kidney using IL17A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat kidney using IL17A antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human stomach using IL17A antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis of mouse eyeball using IL17A antibody.
IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage (1,2). IL-17A stimulates the production of the pro-inflammatory cytokines IL-1β, TNF-α, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity (1,2). IL-17A is intimately involved in mucosal immunity against bacterial infections (1,3) and has a putative role in some autoimmune disorders (1,4). IL-17A effects appear to be exerted primarily through binding to the IL-17RA (5). IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-κB pathways (3,4, 6). Phosphorylation of some Jaks and Stats has been observed.
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