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Our customer service representatives are available 24 hours, Monday through Friday to assist you.Reactivity | Mouse Rat |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
Calculated MW | 86kDa |
Observed MW | Refer to Figures |
Immunogen | A synthetic peptide of human CTNNB1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; β-catenin; |
Immunohistochemistry of paraffin-embedded mouse heart using CTNNB1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat brain using CTNNB1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat heart using CTNNB1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse liver using CTNNB1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse heart using CTNNB1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse liver using CTNNB1 antibody at dilution of 1:100 (40x lens).
β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).
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