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Our customer service representatives are available 24 hours, Monday through Friday to assist you.Reactivity | Human Mouse Rat |
Tested applications | WB IHC IF |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50 |
Calculated MW | 65kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human BIN1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | AMPH2; AMPHL; SH3P9; |
Western blot analysis of extracts of SW620 cell line, using BIN1 antibody.
Immunohistochemistry of paraffin-embedded Human kidney using BIN1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded Rat brain using BIN1 antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis of U2OS cell using BIN1 antibody. Blue: DAPI for nuclear staining.
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
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