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Our customer service representatives are available 24 hours, Monday through Friday to assist you.Reactivity | Human Mouse Rat |
Tested applications | WB IHC IF |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:20 - 1:50 |
Calculated MW | 72kD |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human APLP1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | b |
Synonym | APLP; |
Western blot analysis of extracts of various cell lines, using APLP1 antibody.
Immunohistochemistry of paraffin-embedded rat brain using APLP1 antibody at dilution of 1:200 (400x lens).
Immunohistochemistry of paraffin-embedded mouse brain using APLP1 antibody at dilution of 1:200 (400x lens).
Immunofluorescence analysis of HeLa cell using APLP1 antibody. Blue: DAPI for nuclear staining.
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
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