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Tested applications | WB ICC IF |
Recommended Dilution | WB 1:500 - 1:2000 ICC 1:50 - 1:200 IF 1:50 - 1:100 |
Calculated MW | 71 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human ALAS1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | ALAS; MIG4; ALAS3; ALASH; ALAS-H; |
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms.
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