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Our customer service representatives are available 24 hours, Monday through Friday to assist you.Introduction | Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17. |
Synonyms | Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11. |
Source | Escherichia Coli. |
Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
Formulation | Filtered (0.2 |
Solubility | It is recommended to reconstitute the lyophilized Eotaxin in sterile 18M?-cm H2O not less than 100 |
Stability | Lyophilized Eotaxin althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution CCL11 should be stored at 4C between 2-7 days and for future use below -18C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
Amino Acid Sequence | HPGSIPTSCC FTMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTKLGKEICADPKKKWVQD ATKHLDQKLQ TPKP |
Purity | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
Biological Activity | Fully biologically active. Determined by its ability to chemoattract purified blood eosinophils using a concentration range of 0.1-1.0 µg/ml, corresponding to a Specific Activity of 10-100IU/mg. |
Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USEONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
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